Kogene provides a powerful solution
for a molecular diagnostics


PowerChek™ SARS-CoV-2 S-gene Mutation Detection Kit Ver.1.0


1. Delta • Delta plus variants detection system

2. Simultaneous discrimination for for 13 major lineages of VOCs and VOIs
- Delta, Delta plus, Alpha, Beta, Gamma, and other variants

3. SNP detection of S gene by one-step Multiplex Real-time RT-PCR assay

4. High accuracy & specificity

5. Time to result : less than 1 hour (after N/A extraction)

6. Open system for major Real-time PCR instruments

The importance of SARS-CoV-2 variants surveillance

  • The SARS-CoV-2 variants can not only interrupt the formation of herd immunity through vaccination, but also the prevention and efficacy of the medical treatment.
  • It is essential that we monitor SARS-CoV-2 variants in order to prevent further spread of COVID-19 and construct the effective quarantine measures.
  • Simultaneous discrimination for 13 lineages of VOCs (Variant of Concern) & VOIs (Variant of Interest)
    ※ The variants are classified by the US CDC (update : July 13, 2021).
Classification Variant lineage WHO label Attributes
Severity Infectivity Effects for vaccination and treatment Immunity
- SARS-CoV-2 - - - - -
6 lineages of VOCs B.1.1.7 Alpha Increased ▲ Increased ▲ Reduced ▼ Suppression ▼
B.1.1.7 with E484K
B.1.617.2 Delta -
AY.1 & 2 Delta Plus
B.1.351 Beta
P.1 Gamma -
6 lineages of VOIs B.1.427 / 429 Epsilon Increased ▲
B.1.525 Eta
B.1.526.1 Iota -
B.1.617.1 Kappa
B.1.617.3 -
P.2 Zeta
- P.3 Theta

To detect the mutation of RBD in S-gene

  • The spike protein (S-protein) of SARS-CoV-2 plays a crucial role in recognizing the receptor, attaching the host cell, and penetrating into the body.
  • Therefore, monitoring the mutation of receptor binding domain (RBD)* in the S-gene, S-protein coding gene is at utmost importance.
  • The Kit is designed to detect the 6 major SNPs in RBD* of S gene

Testing procedure for SARS-CoV-2 and Variant lineage


  • 2X RT-PCR Master Mix
  • Primer/Probe Mix
  • Control
  • Kit Manual